Antibiotic releasing hydroxyapatite beads.

Use of Antibiotic Beads

The diabetic infecrion .is an entity encountered by countless health professionals on a daily basis and represents one of the most challenging, as well as costly, endeavors in medicine today.' As a disease that requires multidisciplinary involvement, we approach diabetes and its management with a cautious optimism, knowing the ramifications of neglecting this potentially debilitating condition....

Do Antibiotic Beads Need to be Removed?

Background: Polymethylmethacrylate antibiotic impregnated beads can be an effective treatment for chronicosteomyelitis or an adjuvant in the treatment of open fractures. It remains unclear however whether the beads causelong-term adverse events if not removed. The purpose of this study was to determine if removal of antibiotic beads wasrequired in order to avoid long term comp...

In vitro evaluation of antibiotic diffusion from antibiotic-impregnated biodegradable beads and polymethylmethacrylate beads.

Antibiotic-impregnated beads are used in the dead bone space following debridement surgery to deliver local, high concentrations of antibiotics. Polymethylmethacrylate (PMMA), 2,000-molecular-weight (MW) polylactic acid (PLA), Poly(DL-lactide)-coglycolide (PL:CG; 90:10, 80:20, and 70:30), and the combination 2,000-MW PLA-70:20 PL:CG were individually mixed with clindamycin, tobramycin, or vanco...

Treated by Antibiotic-calcium Hydroxyapatite Ceramic Composites

The efficacy of locally implanted antibiotic-calcium hydroxyapatite ceramic composites was investigated for the treatment of experimentally produced, implantrelated osteomyelitis in rats. High concentrations of antibiotics were detected at the site of infection and bacteria were eradicated without removal of the metal implants. Parenteral antibiotics and surgical debridement, alone or in combin...

Antibiotic-impregnated cement and beads for orthopedic infections.